Use пришелепкуватий as an informal Ukrainian adjective, mainly in speech, fiction, jokes, and character description. It can be playful among friends, but it can also sound insulting, so neutral words like дивний or незвичний are safer in careful writing.
Вона пришелепкуватий keeps the masculine form with a feminine subject, and medical or formal contexts need neutral wording rather than this colloquial insult.
The older dictionary record gives пришелепкуватий beside пришелепуватий and glosses it with Russian words meaning knocked about or foolish. A secure deeper origin is not stated in the consulted sources.